Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.65 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901674 | 0.97 | KARS1 (0.62) | KARS1SYKTBK1CKS1BSKP1 | |
| SCHEMBL1704909 | 0.89 | KARS1 (0.67) | KARS1SYKTBK1 | |
| SCHEMBL1704340 | 0.89 | KARS1 (0.64) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL1704773 | 0.88 | KARS1 (0.51) | KARS1SYKTBK1CKS1BSKP1 | |
| SCHEMBL1704884 | 0.88 | KARS1 (0.50) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL1704297 | 0.88 | SYK (0.53) | KARS1SYKTBK1CKS1BSKP1 | |
| SCHEMBL1704662 | 0.87 | KARS1 (0.72) | KARS1SYK | |
| SCHEMBL902920 | 0.85 | SYK (0.50) | KARS1SYKTBK1 | |
| SCHEMBL1704434 | 0.84 | KARS1 (0.68) | KARS1SYK | |
| SCHEMBL902751 | 0.83 | CKS1B (0.47) | KARS1SYKTBK1CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |