Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901905 | 0.90 | KARS1 (0.80) | KARS1 | |
| SCHEMBL902800 | 0.90 | KARS1 (0.60) | KARS1DYRK1ASYK | |
| SCHEMBL902036 | 0.89 | KARS1 (0.81) | KARS1DYRK1A | |
| SCHEMBL901421 | 0.89 | KARS1 (0.82) | KARS1DYRK1A | |
| SCHEMBL901833 | 0.87 | KARS1 (0.72) | KARS1DYRK1ARAB9ANAMPT | |
| SCHEMBL901791 | 0.87 | KARS1 (0.81) | KARS1DYRK1A | |
| SCHEMBL902079 | 0.86 | KARS1 (0.70) | KARS1DYRK1A | |
| SCHEMBL901804 | 0.85 | KARS1 (0.68) | KARS1DYRK1ARAB9A | |
| SCHEMBL901557 | 0.85 | KARS1 (0.65) | KARS1NPC1RAB9A | |
| SCHEMBL901973 | 0.85 | KARS1 (0.69) | KARS1DYRK1ASYKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |