Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DGKA | P23743 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445573 | 0.90 | HPRT1 (0.53) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8842965 | 0.88 | HPRT1 (0.52) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9068090 | 0.84 | HPRT1 (0.58) | HPRT1NOS1HBB | |
| SCHEMBL11244155 | 0.82 | HPRT1 (0.53) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL10481461 | 0.82 | ALDH1A1 (0.47) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL146427 | 0.79 | HPRT1 (0.61) | HPRT1HBB | |
| SCHEMBL6748740 | 0.79 | HPRT1 (0.57) | HPRT1KMT2AMEN1NOS1MAPK1 | |
| SCHEMBL710905 | 0.79 | HPRT1 (0.49) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL710910 | 0.79 | HPRT1 (0.49) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL7222868 | 0.79 | HPRT1 (0.49) | HPRT1KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351215-B1 | Ester of 9-(2-hydroxyethoxymethyl) guanine | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | claimed |
| US-5079252-A | Valeryl ester of acyclovir improves bioavailability of acylclovir, viricides, treatment of herpes | BUROUGHS WELCOME CO. (US) | 1992-01-07 | — | — | US | claimed |
| JP-2073086-A | — | — | None | — | — | JP | disclosed |
| EP-0351215-B1 | Ester of 9-(2-hydroxyethoxymethyl) guanine | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | disclosed |
| US-5079252-A | Valeryl ester of acyclovir improves bioavailability of acylclovir, viricides, treatment of herpes | BUROUGHS WELCOME CO. (US) | 1992-01-07 | — | — | US | disclosed |
| JP-H0273086-A | THERAPEUTIC COMPOUND | WELLCOME FOUND LTD:THE | 1990-03-13 | — | — | JP | disclosed |
| EP-0351215-A2 | Ester of 9-(2-hydroxyethoxymethyl) guanine | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-01-17 | — | — | EP | disclosed |