Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020776 | 0.92 | ABCB1 (0.40) | LMNAABCB1MCL1HDAC8KEAP1 | |
| SCHEMBL9020436 | 0.91 | ABCB1 (0.39) | LMNAABCB1MCL1HDAC8TDP1 | |
| SCHEMBL9020596 | 0.79 | ABCB1 (0.39) | ABCB1MCL1JAK2JAK1GPR119 | |
| SCHEMBL15632378 | 0.78 | ABCB1 (0.39) | LMNAABCB1MCL1HDAC8GPR119 | |
| SCHEMBL9399200 | 0.78 | ATM (0.33) | ABCB1ATM | |
| SCHEMBL4298537 | 0.78 | JAK2 (0.43) | ABCB1MCL1JAK2JAK1GPR119 | |
| SCHEMBL6404153 | 0.77 | HTRA1 (0.38) | LMNAABCB1TDP1JAK2JAK1 | |
| SCHEMBL7859048 | 0.77 | HTRA1 (0.38) | LMNAABCB1TDP1JAK2JAK1 | |
| SCHEMBL7859886 | 0.76 | NR1H2 (0.46) | ABCB1JAK2JAK1 | |
| SCHEMBL7804688 | 0.74 | GPR119 (0.40) | JAK2JAK1GPR119TP53ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449191-B1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5438054-A | Antibacterial agent | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| WO-1991014687-A1 | 2-(SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-10-03 | — | — | WO | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |