Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806059 | 0.80 | PRMT5 (0.36) | GPR119JAK2JAK1PRMT5WDR77 | |
| SCHEMBL7809902 | 0.80 | PRMT5 (0.36) | GPR119JAK2JAK1PRMT5WDR77 | |
| SCHEMBL6404153 | 0.79 | HTRA1 (0.38) | GPR119JAK2JAK1PRMT5WDR77 | |
| SCHEMBL7859048 | 0.79 | HTRA1 (0.38) | GPR119JAK2JAK1PRMT5WDR77 | |
| SCHEMBL4298537 | 0.78 | JAK2 (0.43) | GPR119JAK2JAK1KLK7 | |
| SCHEMBL7804752 | 0.77 | ALDH1A1 (0.39) | GPR119MAPT | |
| SCHEMBL13340712 | 0.77 | GPR119 (0.45) | GPR119JAK2JAK1BCHEPRMT5 | |
| SCHEMBL8120986 | 0.77 | GPR119 (0.45) | GPR119JAK2JAK1BCHEPRMT5 | |
| SCHEMBL7799282 | 0.76 | PRMT5 (0.38) | PRMT5WDR77MAPT | |
| SCHEMBL7859886 | 0.76 | NR1H2 (0.46) | JAK2JAK1KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773222-B1 | CARBAPENEM DERIVATIVE | EISAI CO LTD (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-6037341-A | HAVING POTENT ANTIMICROBIAL EFFECTS OVER GRAM-POSITIVE BACTERIA AND GRAM-NEGATIVE BACTERIA | EISAI CO., LTD. (JP) | 2000-03-14 | — | — | US | disclosed |
| EP-0773222-A1 | NOVEL CARBAPENEM DERIVATIVE | Eisai Co., Ltd. (JP) | 1997-05-14 | — | — | EP | disclosed |