Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222806 | 0.82 | KIT (0.46) | HPGDL3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL28467263 | 0.82 | PDE4A (0.52) | HPGDL3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL322590 | 0.82 | PDE4A (0.52) | HPGDL3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL8886389 | 0.78 | PDE4A (0.56) | HPGDL3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL9020727 | 0.77 | L3MBTL1 (0.43) | HPGDL3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL8006243 | 0.77 | KDM4E (0.32) | HPGDL3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL19461858 | 0.76 | L3MBTL1 (0.50) | HPGDL3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL460078 | 0.76 | L3MBTL1 (0.39) | HPGDL3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL6620154 | 0.74 | DRD2 (0.44) | HPGD | |
| SCHEMBL10107391 | 0.74 | L3MBTL1 (0.70) | HPGDL3MBTL1MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498331-B1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5340936-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-23 | — | — | US | disclosed |
| US-5334599-A | Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT3 receptor antagonists and inhibitors of the reuptake of serotonin | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-02 | — | — | US | disclosed |
| US-5234931-A | Anxiolytic agents; antdepressants; schizophrenia; drug abuse; medical diagnosis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0498331-A1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-12 | — | — | EP | disclosed |