Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022199 | 0.91 | CNR2 (0.44) | CNR2TSHRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9022821 | 0.88 | CNR2 (0.53) | CNR2TSHRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9023262 | 0.76 | NPC1 (0.49) | CNR2ALDH1A1SMN1; SMN2TDP1POLB | |
| SCHEMBL1664496 | 0.75 | LMNA (0.44) | ALDH1A1TDP1POLBRECQLKDM4E | |
| SCHEMBL11332213 | 0.74 | CNR2 (0.49) | CNR2TSHRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28706581 | 0.72 | TSHR (0.41) | CNR2TSHRCYP1A2CYP3A4CYP2C19 | |
| Bicarbonate SCHEMBL29658892 | 0.72 | ALDH1A1 (0.52) | TSHRCYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL27680360 | 0.72 | CA12 (0.49) | CNR2ALDH1A1KDM4E | |
| SCHEMBL5776620 | 0.72 | MEN1 (0.42) | CNR2ALDH1A1SMN1; SMN2TDP1POLB | |
| SCHEMBL1938751 | 0.72 | LMNA (0.42) | ALDH1A1TDP1POLBRECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381141-B1 | Novel aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| CN-1022754-C | Novel aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds preparation method | MERRELL DOW PHARMA (US) | 1993-11-17 | — | — | CN | disclosed |
| US-5041554-A | Replace steroids in treatment of inflammatory diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| US-5039695-A | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-13 | — | — | US | disclosed |
| CN-1044653-A | The new aryl or the heteroaryl-I-alkyl-pyrroles-2-carboxylic acid that are used for the treatment of the pathological state of interleukin-I mediation | MERRELL DOW PHARMA (US) | 1990-08-15 | — | — | CN | disclosed |
| EP-0381141-A2 | Novel aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions | MERRELL PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| EP-0381142-A2 | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | disclosed |