Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.57 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366361 | 0.89 | ALOX5 (0.74) | ALOX5ADAM17 | |
| SCHEMBL9370317 | 0.88 | ALOX5 (0.55) | ALOX5MAOBADAM17BCHEHTR2B | |
| SCHEMBL9365968 | 0.85 | ALOX5 (0.44) | ALOX5MAOBHTR2BTMEM97SIGMAR1 | |
| SCHEMBL9582882 | 0.81 | ALOX5 (0.52) | ALOX5ADAM17HTR1A | |
| SCHEMBL9368934 | 0.79 | ALOX5 (0.64) | ALOX5ADAM17 | |
| SCHEMBL9583811 | 0.78 | ALOX5 (0.66) | ALOX5ADAM17 | |
| SCHEMBL9244988 | 0.77 | ALOX5 (0.36) | ALOX5 | |
| SCHEMBL9023108 | 0.77 | ACHE (0.42) | — | |
| SCHEMBL9022255 | 0.76 | ALOX5 (0.58) | ALOX5ADAM17 | |
| SCHEMBL9364733 | 0.76 | ALOX5 (0.60) | ALOX5ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385679-B1 | Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase | ZENECA LTD (GB) | 1996-04-24 | — | — | EP | disclosed |
| US-5302603-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | disclosed |
| EP-0375457-B1 | Cyclic ether derivatives | ICI PLC (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5219881-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| US-5196419-A | Lipoxygenase enzyme inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-23 | — | — | US | disclosed |
| US-5098932-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC, ICI PHARMA (FR) | 1992-03-24 | — | — | US | disclosed |
| EP-0375457-A2 | Cyclic ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |