Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.58 |
| ▸ | GRM5 | P41594 | 13/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582882 | 0.87 | ALOX5 (0.52) | ALOX5GRM5KCNH2ADAM17 | |
| SCHEMBL9022908 | 0.76 | ALOX5 (0.57) | ALOX5ADAM17 | |
| SCHEMBL9370985 | 0.76 | ALOX5 (0.41) | ALOX5GRM5KCNH2 | |
| SCHEMBL9365136 | 0.74 | ALOX5 (0.39) | ALOX5GRM5 | |
| SCHEMBL9213851 | 0.73 | ALOX5 (1.00) | ALOX5GRM5 | |
| SCHEMBL9366361 | 0.73 | ALOX5 (0.74) | ALOX5ADAM17 | |
| SCHEMBL5698315 | 0.72 | GRM5 (1.00) | ALOX5GRM5 | |
| SCHEMBL9218764 | 0.71 | ALOX5 (0.67) | ALOX5GRM5ADAM17 | |
| SCHEMBL9124587 | 0.71 | ALOX5 (0.61) | ALOX5GRM5ADAM17 | |
| SCHEMBL9124584 | 0.71 | ALOX5 (0.61) | ALOX5GRM5ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385679-B1 | Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase | ZENECA LTD (GB) | 1996-04-24 | — | — | EP | claimed |
| US-5302603-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | claimed |
| EP-0385679-A2 | Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | claimed |
| EP-0385679-B1 | Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase | ZENECA LTD (GB) | 1996-04-24 | — | — | EP | disclosed |
| US-5302603-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | disclosed |
| US-5196419-A | Lipoxygenase enzyme inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-23 | — | — | US | disclosed |
| EP-0385679-A2 | Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |