Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17617109 | 0.75 | MMP8 (0.41) | — | |
| Ammonia Solution, Strong SCHEMBL28085900 | 0.73 | MMP8 (0.40) | — | |
| SCHEMBL28972395 | 0.73 | TSHR (0.33) | — | |
| SCHEMBL527061 | 0.71 | CA4 (0.39) | MMP1MMP2MMP3CA4 | |
| SCHEMBL2649989 | 0.70 | CA4 (0.37) | CA4 | |
| SCHEMBL7655070 | 0.70 | PEPD (0.38) | CA4 | |
| SCHEMBL13166436 | 0.69 | TAS1R3 (0.33) | MMP1MMP2MMP3 | |
| SCHEMBL1959317 | 0.69 | MEN1 (0.31) | — | |
| SCHEMBL28972441 | 0.68 | TSHR (0.46) | — | |
| SCHEMBL9718192 | 0.67 | CA4 (0.34) | CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5468898-A | Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-11-21 | — | — | US | disclosed |
| US-5232948-A | SUBSTITUTED MONOCYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1992004315-A1 | SUBSTITUTED MONOCYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-03-19 | — | — | WO | disclosed |