Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527061 | 0.76 | CA4 (0.39) | CA4LPAR3LPAR1LPAR2PEPD | |
| SCHEMBL7655070 | 0.74 | PEPD (0.38) | CA4LPAR3LPAR1LPAR2PEPD | |
| SCHEMBL2649989 | 0.74 | CA4 (0.37) | CA4LPAR3LPAR1LPAR2PEPD | |
| SCHEMBL27883038 | 0.72 | CA4 (0.43) | CA4PEPDFDPSKDM4ECYP2C19 | |
| SCHEMBL28531153 | 0.70 | CA4 (0.42) | CA4PEPDFDPSKDM4ECYP2C19 | |
| SCHEMBL23466367 | 0.69 | FDPS (0.39) | CA4LPAR3LPAR1LPAR2FDPS | |
| SCHEMBL11409474 | 0.69 | CA4 (0.40) | CA4PEPDFDPS | |
| SCHEMBL11347820 | 0.68 | PEPD (0.33) | CA4LPAR3LPAR1LPAR2PEPD | |
| SCHEMBL2488147 | 0.67 | CA4 (0.43) | CA4PEPDFDPS | |
| SCHEMBL9023029 | 0.67 | MMP1 (0.32) | CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320777-B1 | A NOVEL APPROACH TO PRODUCE NATURAL VITAMIN E MAKING USE OF AN ASYMMETRIC SYNTHESIS | F. HOFFMANN-LA ROCHE AG (CH) | 1992-03-18 | — | — | EP | disclosed |
| US-4913851-A | Asymmetric synthesis of natural vitamin E. | HOFFMANN-LA ROCHE INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4914217-A | Asymmetric synthesis of natural vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4900476-A | Quinone intermediates for asymmetric synthesis of natural vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4898953-A | Natural Vitamin E intermediate | HOFFMANN-LA ROCHE INC. (US) | 1990-02-06 | — | — | US | disclosed |
| US-4898962-A | Natural vitamin E intermediate | HOFFMANN-LA ROCHE INC. (US) | 1990-02-06 | — | — | US | disclosed |
| US-4855085-A | Asymmetric synthesis of natural vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0320777-A2 | A novel approach to produce natural vitamin E making use of an asymmetric synthesis | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |
| US-4831185-A | Asymmetric synthesis of natural vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1989-05-16 | — | — | US | disclosed |