Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901538 | 0.88 | KARS1 (0.60) | KARS1SIGMAR1CDK9HTR2C | |
| SCHEMBL901298 | 0.85 | KARS1 (0.64) | KARS1 | |
| SCHEMBL902213 | 0.82 | KARS1 (0.40) | KARS1SIGMAR1CDK9HTR2C | |
| SCHEMBL902960 | 0.80 | GSK3A (0.43) | SIGMAR1HTR2C | |
| SCHEMBL1755681 | 0.80 | KARS1 (0.56) | KARS1 | |
| SCHEMBL901948 | 0.79 | KARS1 (0.46) | KARS1CDK9 | |
| SCHEMBL1755672 | 0.79 | KARS1 (0.49) | KARS1CDK9 | |
| SCHEMBL1704397 | 0.75 | KARS1 (0.77) | KARS1 | |
| SCHEMBL1704352 | 0.74 | GRM1 (0.46) | KARS1 | |
| SCHEMBL901243 | 0.73 | KARS1 (0.59) | KARS1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |