Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705140 | 0.86 | KDR (0.42) | KARS1HTR2CSIGMAR1CDK9HTR6 | |
| SCHEMBL902309 | 0.82 | KARS1 (0.49) | KARS1HTR2CSIGMAR1CDK9 | |
| SCHEMBL901538 | 0.81 | KARS1 (0.60) | KARS1HTR2CSIGMAR1CDK9 | |
| SCHEMBL902895 | 0.81 | AURKA (0.41) | HTR2CSIGMAR1HTR6 | |
| SCHEMBL901298 | 0.75 | KARS1 (0.64) | KARS1 | |
| SCHEMBL11963492 | 0.74 | KHK (0.44) | KARS1HTR2CSIGMAR1CDK9CDK4 | |
| SCHEMBL902803 | 0.74 | PDE10A (0.45) | CDK9CCNT1HTR6 | |
| SCHEMBL901708 | 0.74 | KARS1 (0.66) | KARS1 | |
| SCHEMBL902808 | 0.74 | SYK (0.43) | KARS1KDR | |
| SCHEMBL1755681 | 0.70 | KARS1 (0.56) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |