Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704842 | 0.91 | KARS1 (0.52) | KARS1ALDH1A1SMN1; SMN2NAMPTALOX15 | |
| SCHEMBL901769 | 0.89 | KARS1 (0.60) | KARS1ALDH1A1SMN1; SMN2NAMPTALOX15 | |
| SCHEMBL1704352 | 0.88 | GRM1 (0.46) | KARS1NAMPTSYK | |
| SCHEMBL1705014 | 0.85 | ALDH1A1 (0.44) | KARS1ALDH1A1SMN1; SMN2NAMPTALOX15 | |
| SCHEMBL901761 | 0.82 | KARS1 (0.54) | KARS1ALDH1A1SMN1; SMN2NAMPTCDK9 | |
| SCHEMBL1704307 | 0.81 | KARS1 (0.49) | KARS1NAMPT | |
| SCHEMBL901335 | 0.80 | KARS1 (0.44) | KARS1NAMPTCDK9 | |
| SCHEMBL1704634 | 0.80 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2NAMPTALOX15TSHR | |
| SCHEMBL901564 | 0.79 | KARS1 (0.42) | KARS1NAMPTCDK9 | |
| SCHEMBL901565 | 0.79 | KARS1 (0.42) | KARS1NAMPTCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |