Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023557 | 0.92 | MEN1 (0.34) | KMT2AMEN1USP2SMN1; SMN2ACHE | |
| SCHEMBL9024129 | 0.90 | ABCB1 (0.36) | KMT2AMEN1USP2SMN1; SMN2NQO2 | |
| SCHEMBL9024175 | 0.87 | NQO2 (0.40) | NQO2SMARCA2 | |
| SCHEMBL9024039 | 0.87 | NQO2 (0.43) | NQO2SMARCA2 | |
| SCHEMBL9023606 | 0.84 | ALDH1A1 (0.34) | KMT2AMEN1NQO2ESR1KDM5A | |
| SCHEMBL9024529 | 0.80 | KDM1A (0.34) | KMT2AMEN1NQO2ALDH1A1GAA | |
| SCHEMBL9024132 | 0.77 | ALDH1A1 (0.33) | KMT2AMEN1ESR1KDM5AESR2 | |
| SCHEMBL9023725 | 0.77 | MAPT (0.38) | KMT2AMEN1NQO2ESR1KDM5A | |
| SCHEMBL8543303 | 0.76 | NQO2 (0.44) | NQO2SMARCA2 | |
| SCHEMBL9024054 | 0.76 | TOP2A (0.38) | NQO2ALDH1A1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |