Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.59 |
| ▸ | LTB4R2 | Q9NPC1 | 18/20 | 0.59 |
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802375 | 0.74 | LTB4R (0.46) | LTB4RLTB4R2TSPO | |
| SCHEMBL9023215 | 0.73 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7263191 | 0.72 | NPC1 (0.53) | — | |
| SCHEMBL9022721 | 0.71 | LTB4R (0.67) | LTB4RLTB4R2 | |
| SCHEMBL9022885 | 0.71 | LTB4R (0.81) | LTB4RLTB4R2 | |
| SCHEMBL9023216 | 0.71 | LTB4R (0.86) | LTB4RLTB4R2 | |
| SCHEMBL9022963 | 0.70 | LTB4R (0.93) | LTB4RLTB4R2 | |
| SCHEMBL9023069 | 0.70 | LTB4R (0.57) | LTB4RLTB4R2 | |
| SCHEMBL9023135 | 0.69 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL9023084 | 0.69 | LTB4R (0.91) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5468898-A | Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |