SCHEMBL902364

SCHEMBL902364

NNC(=O)NCC(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 2/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
LOXL2 Q9Y4K0 1/20 0.34
DGAT1 O75907 1/20 0.32
CETP P11597 1/20 0.32
ALDH1A1 P00352 3/20 0.32
POLB P06746 2/20 0.31
CYP1A2 P05177 1/20 0.30
TSHR P16473 1/20 0.30
NFKB1 P19838 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30
THPO P40225 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1695238 0.98 SMN1; SMN2 (0.42) SMN1; SMN2LMNAHTTL3MBTL1LOXL2
SCHEMBL9348376 0.84 SMN1; SMN2 (0.53) SMN1; SMN2LMNAHTTL3MBTL1LOXL2
SCHEMBL15923866 0.76 CFTR (0.36) SMN1; SMN2DGAT1ALDH1A1POLBMEN1
SCHEMBL26333091 0.75 SMN1; SMN2 (0.43) SMN1; SMN2LMNAHTTL3MBTL1LOXL2
SCHEMBL17028976 0.75 SMN1; SMN2 (0.43) SMN1; SMN2LMNAHTTL3MBTL1LOXL2
SCHEMBL965910 0.75 SMN1; SMN2 (0.43) SMN1; SMN2LMNAHTTL3MBTL1CETP
SCHEMBL21680801 0.75 L3MBTL1 (0.40) SMN1; SMN2LMNAHTTL3MBTL1LOXL2
SCHEMBL308777 0.74
Hydrochloric Acid SCHEMBL2531654 0.73 SMN1; SMN2 (0.42) SMN1; SMN2LMNAHTTL3MBTL1CETP
SCHEMBL124496 0.73 SMN1; SMN2 (0.46) SMN1; SMN2LMNAHTTL3MBTL1CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3408263-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO Dow Agrosciences LLC (US) 2018-12-05 EP disclosed
WO-2017132021-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-08-03 WO disclosed
EP-3199530-A1 BENZOFURAN ANALOGUE AS NS4B INHIBITOR Changzhou Yinsheng Pharmaceutical Co., Ltd. (CN) 2017-08-02 EP disclosed
WO-2015165960-A1 N-ACYLAMIDINE COMPOUNDS BASF SE (DE) 2015-11-05 WO disclosed
WO-2015124606-A1 N-SUBSTITUTED IMINO HETEROCYCLIC COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2015-08-27 WO disclosed
US-8653000-B2 Imine substituted 2,4-diaryl-pyrroline derivatives as pesticides BASF SE (DE) 2014-02-18 US disclosed
EP-2621900-A1 IMINE SUBSTITUTED 2, 4 - DIARYL - PYRROLINE DERIVATIVES AS PESTICIDES BASF SE (DE) 2013-08-07 EP disclosed
CN-103228627-A Imine substituted 2, 4-diaryl pyrroline derivatives as pesticides BASF SE 2013-07-31 CN disclosed
US-20130190378-A1 Imine substituted 2,4-diaryl-pyrroline derivatives as pesticides BASF SE (DE) 2013-07-25 US disclosed
WO-2012042007-A1 IMINE SUBSTITUTED 2, 4 - DIARYL - PYRROLINE DERIVATIVES AS PESTICIDES BASF SE (DE) 2012-04-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190378-A1 Imine substituted 2,4-diaryl-pyrroline derivatives as pesticides DDT, PIR, INMT SMN1; SMN2 875/4885LMNA 2341/4885HTT 201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.