Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 8/20 | 0.38 |
| ▸ | NQO1 | P15559 | 6/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025257 | 0.86 | KDM4E (0.40) | KDM4ELMNANQO2NQO1MAPT | |
| SCHEMBL9024950 | 0.84 | AR (0.40) | KDM4ELMNANPY5RTP53NQO2 | |
| SCHEMBL9024798 | 0.78 | NQO2 (0.56) | KDM4ELMNANQO2NQO1 | |
| SCHEMBL9023798 | 0.74 | MAPT (0.41) | KDM4ELMNANQO2NQO1MAPT | |
| SCHEMBL9023793 | 0.74 | ALDH1A1 (0.41) | KDM4ELMNATP53NQO2NQO1 | |
| SCHEMBL9025389 | 0.72 | KDM1A (0.41) | KDM4ELMNANQO2NQO1MAPT | |
| SCHEMBL9025371 | 0.70 | CYP1A2 (0.44) | KDM4ELMNAMAPTHTT | |
| SCHEMBL16747994 | 0.62 | TP53 (0.48) | KDM4ELMNANPY5RTP53AR | |
| SCHEMBL9024106 | 0.62 | NQO2 (0.47) | NQO2NQO1 | |
| SCHEMBL914296 | 0.61 | PDK1 (0.70) | KDM4ELMNATP53JAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |