Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952807 | 0.92 | SIGMAR1 (0.45) | HPGDSSIGMAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6973877 | 0.88 | CYP3A4 (0.45) | HPGDSCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6972535 | 0.86 | KDM4C (0.38) | HPGDSCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6968013 | 0.86 | KDM4C (0.40) | HPGDSPHF8CYP11B1CYP11B2KDM5A | |
| SCHEMBL6965586 | 0.85 | THRB (0.39) | CYP2A6CYP2B6PHF8CYP19A1CYP11B1 | |
| SCHEMBL6972346 | 0.85 | PHF8 (0.38) | HPGDSSIGMAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6974237 | 0.85 | CDK5 (0.51) | SIGMAR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30741761 | 0.84 | HPGDS (0.50) | HPGDSSIGMAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6968287 | 0.82 | NR1H2 (0.38) | PHF8ALDH1A1KDM5AKDM4CKDM5B | |
| SCHEMBL6958763 | 0.82 | PHF8 (0.34) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | claimed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | claimed |
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1028948-B1 | PHENYL-ALKYL-IMIDAZOLES AS H3 RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6034251-A | ANTIALLERGENS; ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | SCHERING CORPORATION (US) | 2000-03-07 | — | — | US | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |