Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9024199 | 0.99 | PTGS2 (0.44) | PTGS2AGTR1AGTR2KDM4EMEN1 | |
| SCHEMBL9025445 | 0.92 | PTGS2 (0.37) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9024194 | 0.92 | PTGS2 (0.37) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9024187 | 0.92 | PTGS2 (0.37) | PTGS2AGTR1AGTR2 | |
| Water SCHEMBL9374103 | 0.90 | PTGS2 (0.41) | PTGS2KDM4EFABP4TP53MAPT | |
| SCHEMBL9023830 | 0.84 | AGTR1 (0.46) | AGTR1AGTR2MAPT | |
| SCHEMBL9024858 | 0.82 | AGTR1 (0.46) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9024107 | 0.82 | PTGS2 (0.46) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9433660 | 0.81 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9024606 | 0.81 | AGTR1 (0.47) | PTGS2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | claimed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | claimed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | claimed |