Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024194 | 1.00 | PTGS2 (0.37) | PTGS2AGTR1AGTR2USP1WDR48 | |
| SCHEMBL9024187 | 0.99 | PTGS2 (0.37) | PTGS2AGTR1AGTR2USP1WDR48 | |
| SCHEMBL9024201 | 0.92 | PTGS2 (0.45) | PTGS2AGTR1AGTR2 | |
| Water SCHEMBL9024199 | 0.91 | PTGS2 (0.44) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9025788 | 0.86 | PTGS2 (0.34) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9024382 | 0.86 | PTGS2 (0.34) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9025777 | 0.85 | PTGS2 (0.33) | PTGS2AGTR1AGTR2 | |
| Water SCHEMBL9434379 | 0.85 | PTGS2 (0.33) | PTGS2AGTR1AGTR2 | |
| SCHEMBL9023830 | 0.82 | AGTR1 (0.46) | AGTR1AGTR2USP1WDR48 | |
| Water SCHEMBL9374103 | 0.82 | PTGS2 (0.41) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | claimed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | claimed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | claimed |