Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405743 | 0.89 | LMNA (0.42) | LMNALTB4R2SLC6A3SCN1ASCN2A | |
| SCHEMBL4529398 | 0.85 | LMNA (0.50) | LMNALTB4R2SCN1ASCN2ASCN3A | |
| SCHEMBL9024484 | 0.84 | LMNA (0.47) | LMNALTB4R2SLC6A3SCN1ASCN2A | |
| SCHEMBL9405741 | 0.81 | LMNA (0.42) | LMNALTB4R2SLC6A3SCN1ASCN2A | |
| SCHEMBL5863187 | 0.77 | TSHR (0.57) | LMNALTB4R2SLC6A3SCN1ASCN2A | |
| SCHEMBL16125429 | 0.77 | BRS3 (0.41) | LTB4R2SLC6A3ALDH1A1CES2CES1 | |
| SCHEMBL562 | 0.77 | SLC6A3 (0.68) | LMNALTB4R2SLC6A3SLC6A4KMT2A | |
| SCHEMBL29390423 | 0.77 | SLC6A3 (0.68) | LMNALTB4R2SLC6A3SLC6A4KMT2A | |
| SCHEMBL365731 | 0.76 | LTB4R2 (0.57) | LTB4R2CES2CES1 | |
| SCHEMBL29502712 | 0.76 | LTB4R2 (0.57) | LTB4R2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |