Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503544 | 0.88 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7499074 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1PTGDR2 | |
| SCHEMBL8549078 | 0.79 | PTGS2 (0.40) | PTGS2PTGS1SMN1; SMN2PTGDR2CYP1A2 | |
| SCHEMBL9026582 | 0.79 | PTGS2 (0.64) | PTGS2PTGS1TP53SMN1; SMN2CYP3A4 | |
| SCHEMBL9025662 | 0.78 | PTGS2 (0.59) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL8549766 | 0.76 | PTGS2 (0.71) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL9025785 | 0.76 | PTGS2 (0.60) | PTGS2PTGS1TP53SMN1; SMN2 | |
| SCHEMBL7868750 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1PTGDR2CYP3A4HPGD | |
| SCHEMBL8558824 | 0.75 | PTGS2 (0.45) | PTGS2PTGS1PTGDR2 | |
| SCHEMBL9029716 | 0.73 | PTGS2 (0.59) | PTGS2PTGS1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |