⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902646 | 0.91 | KDM5A (0.31) | — | |
| SCHEMBL901756 | 0.86 | MAPKAPK2 (0.35) | — | |
| SCHEMBL902378 | 0.84 | NR3C2 (0.34) | — | |
| SCHEMBL902665 | 0.84 | GPR52 (0.36) | — | |
| SCHEMBL902594 | 0.81 | PDE10A (0.35) | — | |
| SCHEMBL902108 | 0.78 | CCR2 (0.34) | — | |
| SCHEMBL902186 | 0.78 | PRKAB2 (0.36) | — | |
| SCHEMBL902427 | 0.77 | CCNT1 (0.33) | — | |
| SCHEMBL902442 | 0.76 | CHEK1 (0.34) | — | |
| SCHEMBL902240 | 0.70 | CCR2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252951-A1 | 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | PROXIMAGEN LIMITED (GB) | 2013-09-26 | — | — | US | disclosed |
| EP-2621928-A1 | 7-HYDROXY-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | Proximagen Limited (GB) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041817-A1 | 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | PROXIMAGEN LTD (GB) | 2012-04-05 | — | — | WO | disclosed |