Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701642 | 0.88 | HTR2C (0.43) | HTR2CDRD2HTR2ADRD4DRD3 | |
| SCHEMBL9024113 | 0.87 | HTR2C (0.54) | HTR2CDRD2DRD4DRD3ADRA1D | |
| SCHEMBL9687660 | 0.86 | HTR2C (0.56) | HTR2CDRD2HTR2ADRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9023938 | 0.85 | HTR2C (0.56) | HTR2CDRD2HTR2ADRD4DRD3 | |
| SCHEMBL9474916 | 0.82 | HTR2C (0.53) | HTR2CDRD2DRD4ADRA1DADRA1A | |
| SCHEMBL9688546 | 0.82 | HTR2C (0.56) | HTR2CDRD2HTR2ADRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9445171 | 0.81 | HTR2C (0.53) | HTR2CDRD2DRD4ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9023951 | 0.81 | HTR2C (0.55) | HTR2CDRD2HTR2ADRD4DRD3 | |
| SCHEMBL9445175 | 0.79 | HTR2C (0.51) | HTR2CDRD2HTR2ATACR3ADRA1D | |
| SCHEMBL9445139 | 0.79 | HDAC1 (0.41) | HTR2CDRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-B1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5256672-A | Antipsychotic, analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-26 | — | — | US | disclosed |
| US-5180834-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-19 | — | — | US | disclosed |
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |