Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700487 | 0.88 | HTR2C (0.43) | HTR2CDRD2HTR2AKDM4EALDH1A1 | |
| SCHEMBL9024747 | 0.88 | HTR2C (0.57) | HTR2CDRD2HTR2ATACR3DRD4 | |
| SCHEMBL9024113 | 0.77 | HTR2C (0.54) | HTR2CDRD2ALDH1A1DRD4DRD3 | |
| SCHEMBL9687660 | 0.76 | HTR2C (0.56) | HTR2CDRD2HTR2ADRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9023938 | 0.75 | HTR2C (0.56) | HTR2CDRD2HTR2ADRD4DRD3 | |
| SCHEMBL9474916 | 0.72 | HTR2C (0.53) | HTR2CDRD2DRD4MAPTADRA1D | |
| SCHEMBL9688546 | 0.72 | HTR2C (0.56) | HTR2CDRD2HTR2AKDM4EALDH1A1 | |
| SCHEMBL9445139 | 0.72 | HDAC1 (0.41) | HTR2CDRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9445171 | 0.71 | HTR2C (0.53) | HTR2CDRD2DRD4MAPTADRA1D | |
| Hydrochloric Acid SCHEMBL9023951 | 0.71 | HTR2C (0.55) | HTR2CDRD2HTR2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |