Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.60 |
| ▸ | USP1 | O94782 | 1/20 | 0.47 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025759 | 0.85 | USP1 (0.45) | AGTR2USP1WDR48KDM4EMEN1 | |
| SCHEMBL9024448 | 0.83 | AGTR2 (0.52) | AGTR2MAPTBDKRB1LTB4R2PPARG | |
| SCHEMBL9024952 | 0.80 | AGTR2 (0.48) | AGTR2BDKRB1LTB4R2PPARGAGTR1 | |
| Water SCHEMBL9023803 | 0.79 | AGTR2 (0.48) | AGTR2BDKRB1LTB4R2PPARGAGTR1 | |
| Water SCHEMBL9023809 | 0.79 | AGTR2 (0.48) | AGTR2BDKRB1LTB4R2PPARGAGTR1 | |
| SCHEMBL9385126 | 0.78 | AGTR2 (0.69) | AGTR2USP1WDR48MEN1KMT2A | |
| SCHEMBL9387315 | 0.77 | AGTR2 (0.68) | AGTR2USP1WDR48MEN1KMT2A | |
| SCHEMBL9384503 | 0.75 | AGTR2 (0.62) | AGTR2USP1WDR48MEN1KMT2A | |
| SCHEMBL3058636 | 0.75 | CD38 (0.56) | HTTBDKRB1LTB4R2 | |
| SCHEMBL7323049 | 0.75 | AGTR2 (1.00) | AGTR2USP1WDR48BDKRB1LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | claimed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | claimed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | disclosed |