Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | BRS3 | P32247 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9023803 | 0.99 | AGTR2 (0.48) | AGTR2LTB4R2BRS3PTGS2AGTR1 | |
| Water SCHEMBL9023809 | 0.99 | AGTR2 (0.48) | AGTR2LTB4R2BRS3PTGS2AGTR1 | |
| SCHEMBL9024448 | 0.92 | AGTR2 (0.52) | AGTR2LTB4R2PTGS2AGTR1BDKRB1 | |
| SCHEMBL9024959 | 0.85 | PTGS2 (0.41) | PTGS2 | |
| SCHEMBL9024615 | 0.82 | BDKRB1 (0.52) | PTGS2BDKRB1 | |
| SCHEMBL9024837 | 0.80 | AGTR2 (0.60) | AGTR2LTB4R2PTGS2AGTR1BDKRB1 | |
| SCHEMBL9024194 | 0.78 | PTGS2 (0.37) | AGTR2PTGS2AGTR1 | |
| SCHEMBL9025445 | 0.78 | PTGS2 (0.37) | AGTR2PTGS2AGTR1 | |
| SCHEMBL9024454 | 0.77 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL9024187 | 0.77 | PTGS2 (0.37) | AGTR2PTGS2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | claimed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | claimed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | claimed |