Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | PYGM | P11217 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024887 | 0.89 | RIPK1 (0.40) | SCN9ARIPK1TRPV1PYGLPYGM | |
| SCHEMBL9023873 | 0.86 | RIPK1 (0.41) | CRBNRIPK1PYGLPYGM | |
| SCHEMBL9024319 | 0.86 | RIPK1 (0.39) | CRBNRIPK1PYGLPYGM | |
| SCHEMBL9025748 | 0.85 | PYGL (0.47) | RIPK1PYGLPYGM | |
| SCHEMBL8329105 | 0.85 | PYGL (0.47) | RIPK1PYGLPYGM | |
| SCHEMBL9024163 | 0.84 | SCN9A (0.39) | SCN9ARIPK1TRPV1PYGLPYGM | |
| SCHEMBL9025845 | 0.82 | RIPK1 (0.46) | SCN9ARIPK1TRPV1PYGLPYGM | |
| SCHEMBL9025611 | 0.82 | PYGL (0.36) | SCN9ADDB1CRBNRIPK1XIAP | |
| SCHEMBL9024217 | 0.81 | RIPK1 (0.41) | CRBNRIPK1PYGLPYGM | |
| SCHEMBL8621049 | 0.79 | CRBN (0.38) | SCN9ADDB1CRBNRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |