Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
| ▸ | DRD2 | P14416 | 7/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | DRD3 | P35462 | 5/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26108581 | 0.89 | HTR1A (0.65) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL26492991 | 0.89 | HTR1A (0.65) | HTR1ADRD2HTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL26108377 | 0.87 | DRD2 (0.63) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9260064 | 0.84 | HTR1A (0.60) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7488440 | 0.83 | HTR1A (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL4447104 | 0.83 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9557902 | 0.83 | HTR1A (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL1254644 | 0.82 | HTR1A (0.57) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7656340 | 0.82 | CYP2D6 (0.59) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL8416329 | 0.81 | HTR1A (0.57) | HTR1ADRD2HTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119409681-A | Preparation method of buspirone hydrochloride | 北京华素制药股份有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-119409681-B | Preparation method of buspirone hydrochloride | 北京华素制药股份有限公司 | 2025-12-16 | — | — | CN | disclosed |
| CN-119409681-A | Preparation method of buspirone hydrochloride | 北京华素制药股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-119409681-A | Preparation method of buspirone hydrochloride | 北京华素制药股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | disclosed |
| US-5382586-A | Tranquilizers | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 1995-01-17 | — | — | US | disclosed |
| US-5292739-A | Aryl(or heteroaryl) piperazinylalkylazole derivatives, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-03-08 | — | — | US | disclosed |
| US-5182281-A | (OMEGA-(4-(2-PYRIMIDINYL)-1-PIPERAZINYL)ALKYL)-1H-AZOLE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF COGNITIVE FUNCTIONS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1993-01-26 | — | — | US | disclosed |
| US-5162323-A | 4-Pyrimidinyl-1-/Piperazinylalkyl/-1H-Pyrazole | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-11-10 | — | — | US | disclosed |
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | disclosed |
| US-4423049-A | TRANQUILIZERS | MEAD JOHNSON & COMPANY (US) | 1983-12-27 | — | — | US | disclosed |