Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024298 | 0.86 | HCRTR1 (0.49) | HCRTR2HCRTR1MTNR1BMTNR1APDE4D | |
| SCHEMBL9426824 | 0.85 | MTNR1B (0.48) | MTNR1BMTNR1AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9024245 | 0.84 | LMNA (0.52) | HCRTR2HCRTR1MTNR1BMTNR1AALDH1A1 | |
| SCHEMBL9024220 | 0.84 | BCHE (0.54) | HCRTR1MTNR1BMTNR1AALDH1A1KDM4E | |
| SCHEMBL9025038 | 0.82 | MTNR1B (0.44) | HCRTR1MTNR1BMTNR1APDE4DTBXA2R | |
| SCHEMBL9025364 | 0.82 | MTNR1B (0.50) | MTNR1BMTNR1APDE4D | |
| SCHEMBL9025276 | 0.78 | PDE4D (0.51) | MTNR1BMTNR1APDE4D | |
| SCHEMBL9024153 | 0.76 | MTNR1B (0.56) | MTNR1BMTNR1AMAPK1PDE4D | |
| SCHEMBL8982857 | 0.76 | TBXA2R (0.54) | KDM4ETBXA2R | |
| SCHEMBL21255953 | 0.71 | MTNR1B (0.69) | MTNR1BMTNR1APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501693-B1 | Isoquinoline derivatives | BANYU PHARMA CO LTD (JP) | 1996-08-28 | — | — | EP | disclosed |
| US-5362736-A | Alkoxy derivatives for cardiovascular disorders | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0501693-A1 | Isoquinoline derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1992-09-02 | — | — | EP | disclosed |