Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024444 | 0.87 | ALOX5 (0.44) | ALOX5MAPK8MEN1ALDH1A1KMT2A | |
| SCHEMBL527586 | 0.77 | ALOX5 (0.72) | ALOX5EPHX2MEN1ALDH1A1KMT2A | |
| SCHEMBL9025000 | 0.77 | ALOX5 (0.56) | ALOX5EPHX2MAPK8 | |
| SCHEMBL9025191 | 0.76 | ALOX5 (0.58) | ALOX5EPHX2 | |
| SCHEMBL9025062 | 0.75 | ALOX5 (0.56) | ALOX5EPHX2ALDH1A1 | |
| SCHEMBL9025772 | 0.74 | ALOX5 (0.55) | ALOX5EPHX2MEN1ALDH1A1KMT2A | |
| SCHEMBL9282958 | 0.73 | ALOX5 (0.59) | ALOX5EPHX2MEN1ALDH1A1KMT2A | |
| SCHEMBL8305231 | 0.71 | ALOX5 (0.58) | ALOX5EPHX2ALDH1A1 | |
| SCHEMBL8309551 | 0.69 | ALOX5 (1.00) | ALOX5EPHX2MEN1ALDH1A1KMT2A | |
| SCHEMBL9026098 | 0.69 | ALOX5 (0.55) | ALOX5EPHX2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667855-A4 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| EP-0667855-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011342-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-26 | — | — | WO | disclosed |