Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026123 | 1.00 | PTGS2 (0.55) | PTGS2FAAHKCNH2CYP1A2CYP3A4 | |
| SCHEMBL9026297 | 0.88 | PTGS2 (0.53) | PTGS2CYP1A2CYP2C19ALDH1A1PTGS1 | |
| SCHEMBL9026207 | 0.80 | CYP3A4 (0.41) | PTGS2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9037840 | 0.79 | CA1 (0.44) | PTGS2CYP3A4CYP2C19ALDH1A1LMNA | |
| SCHEMBL9024861 | 0.79 | PTGS2 (0.66) | PTGS2PTGS1RXRA | |
| SCHEMBL7502050 | 0.78 | PTGS2 (0.56) | PTGS2FAAHKCNH2CYP1A2CYP3A4 | |
| SCHEMBL7498789 | 0.78 | PTGS2 (0.56) | PTGS2FAAHKCNH2CYP1A2CYP3A4 | |
| SCHEMBL7498544 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL7498729 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL9026427 | 0.77 | PTGS2 (0.43) | PTGS2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |