Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568394 | 0.87 | KDM4E (0.56) | KDM4ESMN1; SMN2POLB | |
| SCHEMBL9027126 | 0.85 | — | — | |
| SCHEMBL9026702 | 0.84 | NPC1 (0.44) | SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL23486367 | 0.80 | KDM4E (0.51) | KDM4E | |
| SCHEMBL9025999 | 0.79 | PDE4D (0.53) | KDM4ESMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL9026556 | 0.79 | SLC5A1 (0.40) | — | |
| SCHEMBL23453742 | 0.78 | KDM4E (0.49) | KDM4ESMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL16260565 | 0.77 | KDM4E (0.57) | KDM4ESMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL7814443 | 0.77 | PDE4D (0.58) | KDM4ESMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL5417372 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725783-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011905-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-05-04 | — | — | WO | disclosed |