Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026964 | 0.91 | CSF1R (0.34) | HDAC8CSF1RMAPTSMN1; SMN2RAB9A | |
| SCHEMBL9026358 | 0.87 | NR4A2 (0.39) | HDAC8MAPTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL9026387 | 0.86 | SCN9A (0.36) | HDAC8CSF1RMAPTSMN1; SMN2RAB9A | |
| SCHEMBL9026581 | 0.76 | ALDH1A1 (0.37) | HPGDALDH1A1LMNAMAPK1NPSR1 | |
| SCHEMBL9026233 | 0.76 | ALDH1A1 (0.40) | SMN1; SMN2HPGDALDH1A1LMNAMAPK1 | |
| SCHEMBL9026857 | 0.75 | MAPK1 (0.37) | SMN1; SMN2RAB9AHPGDALDH1A1LMNA | |
| SCHEMBL27310947 | 0.73 | NR4A2 (0.43) | HDAC8MAPTRAB9AHPGDALDH1A1 | |
| SCHEMBL9027006 | 0.72 | ALDH1A1 (0.38) | HDAC8HPGDALDH1A1LMNAMAPK1 | |
| SCHEMBL9026053 | 0.72 | ALDH1A1 (0.40) | HPGDALDH1A1LMNAMAPK1L3MBTL1 | |
| SCHEMBL9026948 | 0.72 | LMNA (0.39) | HDAC8SMN1; SMN2RAB9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| CN-1024797-C | Indole derivatives | OTSUKA CHEMICAL CO LTD (JP) | 1994-06-01 | — | — | CN | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| CN-1049155-A | INDOLE DERIVATIVES | OTSUKA CHEMICAL CO LTD (JP) | 1991-02-13 | — | — | CN | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |