Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027006 | 0.93 | ALDH1A1 (0.38) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL27258448 | 0.92 | LMNA (0.39) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL9026029 | 0.86 | ALDH1A1 (0.40) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL9026401 | 0.82 | SMN1; SMN2 (0.39) | LMNAHPGDMMP2L3MBTL1KDM4E | |
| SCHEMBL9026581 | 0.81 | ALDH1A1 (0.37) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL9026486 | 0.81 | ALDH1A1 (0.36) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL9026358 | 0.80 | NR4A2 (0.39) | LMNAHPGDALDH1A1MAPK1HTT | |
| SCHEMBL9026201 | 0.80 | LMNA (0.38) | LMNAHPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL9026706 | 0.78 | RAB9A (0.39) | LMNAHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL9026857 | 0.78 | MAPK1 (0.37) | LMNAHPGDALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |