Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026158 | 0.95 | KDM4C (0.36) | KDM4CNPC1RAB9ACFTRHTR2C | |
| SCHEMBL9026594 | 0.89 | KDM4C (0.35) | KDM4CNPC1RAB9ACFTRHTR2C | |
| SCHEMBL9025840 | 0.83 | KDM4C (0.40) | KDM4CNPC1RAB9ACFTRHTR2C | |
| SCHEMBL9026581 | 0.82 | ALDH1A1 (0.37) | HTR2CSLC6A4HTR2A | |
| SCHEMBL9026029 | 0.80 | ALDH1A1 (0.40) | — | |
| SCHEMBL9026486 | 0.79 | ALDH1A1 (0.36) | HTR2CSLC6A4HTR2A | |
| SCHEMBL9025976 | 0.76 | PDE4A (0.35) | HTR2CSLC6A4HTR2A | |
| SCHEMBL9026181 | 0.75 | HTR2C (0.33) | HTR2CSLC6A4HTR2A | |
| SCHEMBL9026300 | 0.74 | PDE4A (0.33) | CFTRHTR2CSLC6A4HTR2A | |
| SCHEMBL9026201 | 0.72 | LMNA (0.38) | HTR2CSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |