Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026223 | 0.90 | PCSK9 (0.39) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9026831 | 0.90 | IDO1 (0.45) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9026518 | 0.90 | GPR84 (0.44) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9027294 | 0.90 | GPR84 (0.44) | GPR84HTR2AHTR1AHTR2CAHR | |
| SCHEMBL9026796 | 0.90 | HTR2C (0.44) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9025829 | 0.87 | MAPT (0.42) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9026919 | 0.83 | AKR1C2 (0.45) | HTR2AHTR1AHTR2CMTNR1BKDM4E | |
| SCHEMBL9027098 | 0.79 | SOS2 (0.43) | HTR2AAHRMAPTNPSR1 | |
| SCHEMBL9486584 | 0.78 | AHR (0.40) | GPR84HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL9027577 | 0.78 | MAPT (0.41) | HTR2AHTR2BHTR1AHTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |