Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026223 | 0.90 | PCSK9 (0.39) | GPR84MTNR1BHTR2AHTR1AMTNR1A | |
| SCHEMBL9026430 | 0.90 | GPR84 (0.51) | GPR84MTNR1BHTR2ATRPM8HTR1A | |
| SCHEMBL9026831 | 0.89 | IDO1 (0.45) | GPR84MTNR1BHTR2ATRPM8HTR1A | |
| SCHEMBL9026796 | 0.89 | HTR2C (0.44) | GPR84HTR2AHTR1AHTR2CHTR2B | |
| SCHEMBL9027294 | 0.89 | GPR84 (0.44) | GPR84MTNR1BHTR2ATRPM8HTR1A | |
| SCHEMBL9025829 | 0.86 | MAPT (0.42) | GPR84HTR2AHTR1AAHRHTR2C | |
| SCHEMBL9027098 | 0.78 | SOS2 (0.43) | HTR2AAHRNR4A2 | |
| SCHEMBL9486584 | 0.78 | AHR (0.40) | GPR84HTR2AHTR1AAHRHTR2C | |
| SCHEMBL9027577 | 0.78 | MAPT (0.41) | HTR2AHTR1AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9026487 | 0.77 | AHR (0.39) | GPR84HTR2AHTR1AAHRHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |