Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | SPR | P35270 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026223 | 0.90 | PCSK9 (0.39) | HTR2CHTR1AHTR2AHTR2BHTR1D | |
| SCHEMBL9026430 | 0.90 | GPR84 (0.51) | HTR2CHTR1AHTR2ACYP2D6NFKB1 | |
| SCHEMBL9026831 | 0.89 | IDO1 (0.45) | HTR2CHTR1AHTR2AHTR2BKMT2A | |
| SCHEMBL9027294 | 0.89 | GPR84 (0.44) | HTR2CHTR1AHTR2ASPRTSHR | |
| SCHEMBL9026518 | 0.89 | GPR84 (0.44) | HTR2CHTR1AHTR2AHTR2BSLC6A4 | |
| SCHEMBL9025829 | 0.86 | MAPT (0.42) | HTR2CHTR1AHTR2ACYP2D6HTR2B | |
| SCHEMBL9027098 | 0.78 | SOS2 (0.43) | HTR2ANPSR1MAPT | |
| SCHEMBL9025614 | 0.78 | AHR (0.41) | KDM4ECYP3A4KMT2AMAPTMEN1 | |
| SCHEMBL9486584 | 0.78 | AHR (0.40) | HTR2CHTR1AHTR2ACYP2D6HTR2B | |
| SCHEMBL9027577 | 0.78 | MAPT (0.41) | HTR2CHTR1AHTR2AHTR2BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |