Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 10/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902494 | 0.85 | IDH2 (0.56) | IDH2SYKKARS1AURKATAS2R14 | |
| SCHEMBL1704561 | 0.77 | KARS1 (0.55) | IDH2SYKKARS1 | |
| SCHEMBL16876450 | 0.74 | TAS2R14 (0.51) | IDH2NOS3NOS2SYKKARS1 | |
| SCHEMBL16392099 | 0.72 | SYK (0.46) | IDH2NOS3NOS2SYKKARS1 | |
| SCHEMBL13737619 | 0.72 | NOS3 (0.49) | IDH2NOS3NOS2SYKMAP3K12 | |
| SCHEMBL28460765 | 0.72 | IDH2 (1.00) | IDH2SYKKARS1MAP3K12 | |
| SCHEMBL17812906 | 0.72 | SYK (0.50) | IDH2NOS3NOS2SYKKARS1 | |
| SCHEMBL901986 | 0.71 | SYK (0.50) | IDH2SYKKARS1 | |
| SCHEMBL16820221 | 0.71 | SYK (0.54) | IDH2NOS3NOS2SYKKARS1 | |
| SCHEMBL13827142 | 0.69 | SYK (0.49) | IDH2NOS3NOS2SYKTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |