Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 3/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771848 | 0.80 | SIGMAR1 (0.41) | ACACBEPHX1KMT2ASIGMAR1MEN1 | |
| SCHEMBL3007047 | 0.79 | MME (0.41) | ACACBEPHX1KMT2ASIGMAR1MEN1 | |
| SCHEMBL9284510 | 0.78 | ACACB (0.42) | ACACBEPHX1KMT2ASIGMAR1MEN1 | |
| SCHEMBL10823884 | 0.78 | SIGMAR1 (0.40) | ACACBEPHX1KMT2ASIGMAR1MEN1 | |
| SCHEMBL10041 | 0.78 | ACACB (0.42) | ACACBEPHX1KMT2ASIGMAR1MEN1 | |
| SCHEMBL17393790 | 0.78 | TAAR1 (0.46) | ACACBEPHX1SIGMAR1PYCR1TAAR1 | |
| SCHEMBL94628 | 0.77 | TAAR1 (0.54) | EPHX1KMT2ASIGMAR1MEN1NPC1 | |
| SCHEMBL1437577 | 0.77 | CHRM1 (0.47) | EPHX1SIGMAR1MME | |
| SCHEMBL1699496 | 0.76 | MME (0.49) | ACACBEPHX1KMT2AMEN1NPC1 | |
| SCHEMBL22236136 | 0.76 | ACACB (0.49) | ACACBEPHX1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |