Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026605 | 1.00 | FOLH1 (0.34) | FOLH1ALDH1A1TDP1MMP1MMP2 | |
| SCHEMBL9164018 | 0.86 | LMNA (0.32) | ALDH1A1LMNAHPGD | |
| SCHEMBL9164020 | 0.86 | LMNA (0.32) | ALDH1A1LMNAHPGD | |
| SCHEMBL8862517 | 0.80 | LMNA (0.33) | ALDH1A1LMNACA2HPGD | |
| SCHEMBL8862515 | 0.80 | LMNA (0.33) | ALDH1A1LMNACA2HPGD | |
| SCHEMBL9163092 | 0.76 | BIRC2 (0.33) | — | |
| SCHEMBL8862880 | 0.73 | ALDH1A1 (0.42) | ALDH1A1TDP1MMP1MMP2MMP3 | |
| SCHEMBL8862881 | 0.73 | ALDH1A1 (0.42) | ALDH1A1TDP1MMP1MMP2MMP3 | |
| SCHEMBL11328030 | 0.69 | ALDH1A1 (0.48) | ALDH1A1TDP1MMP1MMP2MMP3 | |
| SCHEMBL11328029 | 0.69 | ALDH1A1 (0.48) | ALDH1A1TDP1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |