Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | CBS | P35520 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10609249 | 0.79 | IGF1R (0.59) | IGF1RALOX15ALDH1A1PYGL | |
| SCHEMBL10610096 | 0.79 | IGF1R (0.59) | IGF1RALOX15ALDH1A1PYGL | |
| SCHEMBL10606127 | 0.79 | IGF1R (0.59) | IGF1RALOX15ALDH1A1PYGL | |
| SCHEMBL8905774 | 0.79 | IGF1R (0.59) | IGF1RALOX15ALDH1A1PYGL | |
| SCHEMBL9026661 | 0.78 | IGF1R (0.40) | IGF1RALOX15ALDH1A1PTGS2CYP3A4 | |
| SCHEMBL9177319 | 0.78 | IGF1R (0.36) | IGF1RALOX15ALDH1A1PTGS2CYP3A4 | |
| SCHEMBL8861076 | 0.78 | IGF1R (0.36) | IGF1RALOX15ALDH1A1PTGS2CYP3A4 | |
| SCHEMBL9177322 | 0.78 | PTGS2 (0.55) | ALDH1A1PTGS2CYP3A4HSD17B10 | |
| SCHEMBL11199961 | 0.78 | CBS (0.39) | IGF1RALOX15ALDH1A1CBS | |
| SCHEMBL11199932 | 0.78 | IGF1R (0.33) | IGF1RALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |