Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028185 | 0.88 | PRKCI (0.36) | GABRA1GABRB2PRKCIDHFRGAA | |
| SCHEMBL28074175 | 0.80 | GABRA1 (0.50) | GABRA1GABRB2PRKCIDHFRMAPK1 | |
| SCHEMBL9028435 | 0.79 | DHFR (0.37) | GABRA1GABRB2DHFRMAPK1MEN1 | |
| SCHEMBL9571445 | 0.79 | GABRA1 (0.40) | GABRA1GABRB2MAPK1MEN1KMT2A | |
| SCHEMBL9026750 | 0.78 | GABRA1 (0.39) | GABRA1GABRB2MAPK1MEN1KMT2A | |
| SCHEMBL1743958 | 0.74 | PRKCI (0.44) | GABRA1GABRB2PRKCIDHFRMEN1 | |
| SCHEMBL23617749 | 0.74 | GABRA1 (0.61) | GABRA1GABRB2DHFRMAPK1MEN1 | |
| SCHEMBL9028140 | 0.74 | KDM4E (0.38) | GABRA1GABRB2DHFRMAPK1MEN1 | |
| SCHEMBL9027262 | 0.71 | IAPP (0.38) | GABRA1GABRB2PRKCIELANEHTR1A | |
| SCHEMBL10556789 | 0.71 | PRKCI (0.77) | GABRA1GABRB2PRKCIMAPK1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |