Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026754 | 0.88 | GABRA1 (0.40) | PRKCIDHFRKDM4EGLAGAA | |
| SCHEMBL1743958 | 0.81 | PRKCI (0.44) | PRKCIDHFRKDM4EGAAGABRA1 | |
| SCHEMBL9028140 | 0.79 | KDM4E (0.38) | DHFRKDM4EGLAGAAGABRA1 | |
| SCHEMBL9028212 | 0.79 | GABRA1 (0.33) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9028182 | 0.78 | GABRA1 (0.33) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL27644801 | 0.74 | DHFR (0.44) | DHFRKDM4EGLAGAAGABRA1 | |
| SCHEMBL9028435 | 0.74 | DHFR (0.37) | DHFRKDM4EGLAGAAGABRA1 | |
| SCHEMBL28074175 | 0.73 | GABRA1 (0.50) | PRKCIDHFRKDM4EGAAGABRA1 | |
| SCHEMBL29108657 | 0.73 | TYR (0.42) | PRKCIKDM4EGAAGABRA1GABRB2 | |
| SCHEMBL9027584 | 0.71 | MTNR1A (0.46) | KDM4EGAAGABRA1GABRB2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |