Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134426 | 0.94 | SMN1; SMN2 (0.49) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28731533 | 0.90 | ALDH1A1 (0.50) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28731537 | 0.85 | ALDH1A1 (0.46) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11829181 | 0.81 | KMT2A (0.42) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16756212 | 0.80 | L3MBTL1 (0.70) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10338319 | 0.79 | ALDH1A1 (0.53) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31572517 | 0.79 | ALDH1A1 (0.60) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29911025 | 0.79 | ALDH1A1 (0.60) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL57736 | 0.79 | ALDH1A1 (0.60) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28793663 | 0.79 | ALDH1A1 (0.60) | RAB9AL3MBTL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973791-B | Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors | 南京圣和药业股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| CN-107614503-B | Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors | 广东众生药业股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-107614503-A | Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors | 广东众生药业股份有限公司 | 2018-01-19 | — | — | CN | disclosed |
| EP-0706514-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995006034-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1995-03-02 | — | — | WO | disclosed |