Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704236 | 0.77 | KARS1 (0.52) | SYKKARS1BRAF | |
| SCHEMBL902768 | 0.77 | KARS1 (0.52) | SYKKARS1BRAF | |
| SCHEMBL1704640 | 0.75 | KARS1 (0.56) | SYKKARS1BRAF | |
| SCHEMBL1704085 | 0.70 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL1704435 | 0.69 | KARS1 (0.49) | SYKKARS1 | |
| SCHEMBL12971125 | 0.69 | CHRNB2 (0.47) | — | |
| SCHEMBL12818988 | 0.69 | CHRNB2 (0.47) | — | |
| SCHEMBL12143067 | 0.69 | CHRNB2 (0.47) | — | |
| Formic Acid SCHEMBL1367781 | 0.67 | MCHR1 (0.44) | — | |
| SCHEMBL1704571 | 0.66 | SYK (0.46) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |