Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027783 | 0.87 | CYP3A4 (0.42) | PTGS1PTGS2CYP1A2CYP3A4TSHR | |
| SCHEMBL9027208 | 0.85 | — | — | |
| SCHEMBL9027759 | 0.85 | — | — | |
| SCHEMBL9028082 | 0.79 | NR1I2 (0.33) | PTGS1PTGS2CYP1A2CYP3A4TSHR | |
| SCHEMBL9028069 | 0.78 | ALOX5 (0.33) | PTGS1PTGS2CYP1A2CYP3A4TSHR | |
| SCHEMBL6982911 | 0.77 | CYP3A4 (0.50) | PTGS1PTGS2CYP1A2CYP3A4TSHR | |
| SCHEMBL9028328 | 0.75 | DHFR (0.33) | — | |
| SCHEMBL9028319 | 0.75 | — | — | |
| SCHEMBL9571597 | 0.74 | ALDH1A1 (0.34) | CYP1A2CYP3A4EZH2 | |
| SCHEMBL7530465 | 0.72 | CYP3A4 (0.42) | PTGS1PTGS2CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |