Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.64 |
| ▸ | BRPF1 | P55201 | 8/20 | 0.48 |
| ▸ | BRD1 | O95696 | 6/20 | 0.48 |
| ▸ | TAF1 | P21675 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752773 | 0.87 | ATAD2 (0.48) | ATAD2BRPF1BRD1TAF1PKM | |
| SCHEMBL19657546 | 0.84 | ATAD2 (0.71) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL16771511 | 0.78 | ATAD2 (1.00) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL17534190 | 0.77 | ATAD2 (0.68) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL19644300 | 0.77 | ATAD2 (0.47) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL19657544 | 0.74 | ATAD2 (0.59) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL9027061 | 0.74 | ATAD2 (0.44) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL19657848 | 0.72 | ATAD2 (0.57) | ATAD2BRPF1BRD1TAF1HSD17B10 | |
| SCHEMBL19448884 | 0.72 | NQO2 (0.53) | ATAD2BRPF1BRD1HSD17B10BRD4 | |
| SCHEMBL19448887 | 0.72 | BRPF1 (0.53) | ATAD2BRPF1BRD1BRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462831-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5462953-A | Benzoxazolyl derivatives useful as 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-10-31 | — | — | US | disclosed |
| US-5364877-A | Antiinflammatory agents, antiallergens | ICI PHARMA (GB) | 1994-11-15 | — | — | US | disclosed |
| US-5278177-A | Enzyme inhibitory | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-11 | — | — | US | disclosed |
| US-5179115-A | Antiinflammatory agents, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-12 | — | — | US | disclosed |
| EP-0462831-A2 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |